Asparaginase
Rylaze is a recombinant asparaginase medication used as part of chemotherapy regimens for acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma in patients who have developed hypersensitivity to E. coli-derived asparaginase products.
Rylaze is an injectable chemotherapy agent used to treat certain leukemias and lymphomas in patients allergic to standard asparaginase therapy.
Key facts at a glance
- RxNorm
- 2561252
- Generic
- Rylaze
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma in pediatric and adult patients aged 1 month and older who have hypersensitivity reactions to E. coli-derived asparaginase products.
As a form of L-asparaginase, it works by depleting the amino acid asparagine from the blood. Leukemia and lymphoma cells have a high demand for asparagine and cannot synthesize it themselves, making them dependent on external sources; without asparagine, these cancer cells cannot survive and proliferate.
Administered via intramuscular or subcutaneous injection, typically on an alternating schedule with other chemotherapy agents. Requires monitoring for allergic reactions, pancreatitis, hyperglycemia, and coagulation abnormalities. Should not be used in patients with serious hypersensitivity to Erwinia-derived asparaginase products or a history of serious pancreatitis, serious thrombosis, or serious hemorrhagic events with prior asparaginase therapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy