S-Adenosylmethionine
S-Adenosylmethionine (SAMe) is a naturally occurring compound in the body that serves as a key donor for methylation reactions essential to numerous biological processes. It is primarily used as a supplement for mood support in depression and for joint health in osteoarthritis, and may also support liver function.
SAMe is a naturally occurring compound supplement used primarily for mood support and joint health.
Key facts at a glance
- ATC
- A16AA02
- RxNorm
- 9504
- Generic
- S-Adenosylmethionine
- Class
- atc-a16
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
SAMe is commonly used for depressive symptoms and mood support, as well as for osteoarthritis to help reduce joint pain and improve mobility. It may also be used as a liver support supplement in some liver conditions.
SAMe acts as a methyl group donor in over 100 different methylation reactions in the body, including reactions involved in neurotransmitter synthesis (like serotonin and dopamine), cartilage metabolism, and liver cell membrane function. This broad biochemical role supports mood regulation, joint health, and liver function.
SAMe may interact with antidepressant medications and should be used with caution in patients with bipolar disorder due to potential mood-stabilizing or destabilizing effects. It is generally well-tolerated but may cause mild gastrointestinal discomfort in some individuals. Patients should consult their healthcare provider before use, especially if pregnant, nursing, or taking other medications.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy