Sacubitril: Patient Guide for Heart Failure
Sacubitril is a prescription medicine used for long-term heart failure, especially when the heart’s pumping ability is reduced. It is most often taken with valsartan to reduce hospitalizations and death and to help lower strain on the heart. Your doctor or pharmacist will determine whether sacubitril alone or the combination product is appropriate for you.
Sacubitril can improve outcomes for some people with heart failure, but it must be used with careful monitoring for blood pressure, kidney function, and potassium. Do not start, stop, or change the dose without guidance from your doctor or pharmacist.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- RxNorm
- 1656328
- Generic
- Sacubitril
- Class
- unclassified
- Brands
- Entresto
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy