Safinamide
Safinamide is a monoamine oxidase B (MAO-B) inhibitor used as an adjunct treatment for Parkinson's disease. By blocking the enzyme that breaks down dopamine, it helps increase dopamine levels in the brain, improving motor symptoms when used alongside other Parkinson's medications.
Safinamide is an MAO-B inhibitor used to treat Parkinson's disease by increasing dopamine levels in the brain.
Key facts at a glance
- ATC
- N04BD03
- RxNorm
- 1922448
- Generic
- Safinamide
- Class
- atc-n04
- Brands
- Xadago
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Safinamide is indicated as an adjunct treatment to levodopa/carbidopa for patients with Parkinson's disease who experience 'off' episodes (periods when medication wears off and symptoms return).
Safinamide selectively inhibits monoamine oxidase B (MAO-B), the enzyme responsible for breaking down dopamine in the brain. By preventing this breakdown, dopamine levels increase, helping to improve motor function and reduce Parkinson's disease symptoms.
Safinamide should not be used with other MAO inhibitors, certain opioids, or drugs that increase serotonin risk. Patients should avoid foods high in tyramine as interactions can cause hypertensive crisis. It is not recommended for patients with severe liver impairment. Always consult a healthcare provider for complete safety information.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy