Salsalate
Salsalate is a non-steroidal anti-inflammatory drug (NSAID) that is converted to salicylate in the body. It is used to treat pain and inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. Unlike aspirin, it is a non-acetylated salicylate, which may reduce certain side effects like platelet inhibition.
Salsalate is an NSAID used to reduce pain and inflammation in arthritis and related conditions.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N02BA06
- RxNorm
- 36108
- Generic
- Salsalate
- Class
- atc-n02
- Brands
- Disalcid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for symptomatic relief of osteoarthritis and rheumatoid arthritis. May also be used for other painful inflammatory conditions as directed by a healthcare provider.
Salsalate is a prodrug that is hydrolyzed to salicylate, which inhibits cyclooxygenase (COX) enzymes and reduces prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
May cause gastrointestinal side effects similar to other NSAIDs. Use with caution in patients with kidney problems, bleeding disorders, or those taking blood thinners. Avoid in patients with aspirin allergy. Consult your doctor before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy