Collagenase
Santyl is a topical enzymatic debriding agent containing collagenase, an enzyme derived from Clostridium histolyticum. It is used to remove dead tissue (eschar) from chronic wounds, facilitating the wound healing process.
Santyl is a topical ointment used to clean chronic wounds like pressure ulcers and diabetic foot ulcers by breaking down dead tissue.
Key facts at a glance
- RxNorm
- 219803
- Generic
- Santyl
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Santyl is indicated for debriding chronic dermal ulcers and severely burned skin, including pressure ulcers (bedsores), diabetic foot ulcers, and second-degree burns. It helps remove necrotic (dead) tissue to promote healing.
The active ingredient collagenase is an enzyme that specifically breaks down collagen in dead tissue. When applied topically to a wound, it digests the damaged collagen in necrotic tissue, allowing healthy tissue to remain and enabling natural wound healing.
Santyl is for topical use only and should not be applied to wounds with exposed tendon, muscle, or bone. It should not be used on heavily infected wounds. Applications are typically made daily with the wound kept moist. Avoid using with certain antiseptic agents as they may reduce effectiveness. A healthcare provider should monitor progress during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy