Anifrolumab
Saphnelo (anifrolumab) is a prescription biologic medication used to treat moderate to severe systemic lupus erythematosus (SLE) in adults. It is administered as an intravenous infusion and works by blocking the activity of type I interferons, which are proteins involved in inflammation and autoimmune responses.
Saphnelo is a biologic drug used to treat moderate to severe systemic lupus erythematosus (SLE) by targeting type I interferon pathways.
Key facts at a glance
- RxNorm
- 2565282
- Generic
- Saphnelo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Saphnelo is indicated for the treatment of moderate to severe systemic lupus erythematosus (SLE) in adult patients. It is typically used when other standard treatments have not provided adequate symptom control.
Saphnelo is a monoclonal antibody that binds to the type I interferon receptor, blocking the activity of type I interferons. These interferons are believed to play a key role in driving the inflammation and immune dysfunction seen in SLE.
Saphnelo is administered as an intravenous (IV) infusion every 4 weeks by a healthcare professional. Common side effects may include upper respiratory infections, bronchitis, infusion-related reactions, and herpes zoster (shingles). Patients should be monitored for infections during treatment. Live vaccines should be avoided while on therapy. Patients should discuss their complete medical history with their doctor, as Saphnelo may not be suitable for those with severe active infections or certain other conditions.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy