Isatuximab
Sarclisa (isatuximab) is a prescription monoclonal antibody used in combination with other medications to treat adults with multiple myeloma who have received at least two prior therapies. It works by targeting CD38 proteins on cancer cells, helping the immune system recognize and destroy them.
Sarclisa is a targeted immunotherapy used to treat relapsed or refractory multiple myeloma.
Key facts at a glance
- RxNorm
- 2282024
- Generic
- Sarclisa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sarclisa is indicated for the treatment of relapsed or refractory multiple myeloma in adult patients who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor. It is used in combination with pomalidomide and dexamethasone.
Sarclisa is a monoclonal antibody that binds to the CD38 protein found on the surface of multiple myeloma cells. This binding helps the immune system identify and destroy the cancer cells through multiple mechanisms, including antibody-dependent cellular cytotoxicity.
Sarclisa is administered as an intravenous infusion. Common side effects include infusion reactions, neutropenia (low white blood cell counts), and upper respiratory infections. Patients should be monitored for signs of infection and blood count changes. This medication should not be used during pregnancy.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy