Sargramostim
Sargramostim is a granulocyte-macrophage colony-stimulating factor (GM-CSF) that stimulates the production and activation of white blood cells, particularly neutrophils and other immune cells. It is primarily used to treat conditions involving low white blood cell counts, such as chemotherapy-induced neutropenia, bone marrow transplant support, and to mobilize stem cells for collection. By promoting hematopoiesis, it helps reduce the risk of infections in patients with compromised immune function.
A growth factor medication that stimulates white blood cell production to prevent infections in patients with low immune cell counts.
Key facts at a glance
- ATC
- L03AA09
- RxNorm
- 69634
- Generic
- Sargramostim
- Class
- atc-l03
- Brands
- Leukine
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat neutropenia (low neutrophil counts) associated with chemotherapy, bone marrow transplantation, and congenital neutropenia. Also used to mobilize hematopoietic stem cells for peripheral blood progenitor cell collection and transplantation.
Sargramostim binds to GM-CSF receptors on hematopoietic progenitor cells in the bone marrow, stimulating their survival, proliferation, and differentiation into mature white blood cells, particularly neutrophils and macrophages.
Administered by subcutaneous or intravenous injection. Common side effects may include fever, flu-like symptoms, bone pain, and injection site reactions. Should be used with caution in patients with heart or lung conditions. Not indicated for patients with known hypersensitivity to GM-CSF or yeast-derived products.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy