Milnacipran
Savella (milnacipran) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily to manage fibromyalgia symptoms in adults. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps reduce pain and improve mood. It is available only as a brand-name medication and is not currently offered in generic form.
Savella is an SNRI medication prescribed to treat fibromyalgia by increasing serotonin and norepinephrine levels in the brain.
Key facts at a glance
- RxNorm
- 833136
- Generic
- Savella
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Savella is FDA-approved for the management of fibromyalgia in adults, helping to reduce widespread pain, fatigue, and sleep disturbances associated with this chronic condition.
As an SNRI, Savella inhibits the reuptake of both serotonin and norepinephrine in the brain, increasing the availability of these neurotransmitters, which are involved in pain perception and mood regulation.
Common side effects include nausea, headache, dizziness, and increased blood pressure. It should not be used with MAOIs or within 14 days of stopping one. Savella may increase the risk of suicidal thoughts, especially in young adults under 24. Abrupt discontinuation should be avoided; doses must be tapered gradually under medical supervision. Pregnant or nursing women should discuss risks with their healthcare provider before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy