Asciminib
Scemblix is a prescription medication used to treat adults with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase who have previously been treated with other tyrosine kinase inhibitors. It is also approved for patients with the T315I mutation. This oral medication offers an alternative treatment option for patients whose disease has become resistant to standard therapies.
Scemblix is an oral medication for certain types of chronic myeloid leukemia that has become resistant to other treatments.
Key facts at a glance
- RxNorm
- 2584321
- Generic
- Scemblix
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Scemblix is indicated for the treatment of adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase who have been previously treated with two or more tyrosine kinase inhibitors. It is also approved for patients with the T315I mutation.
Scemblix is a tyrosine kinase inhibitor that works by specifically binding to the ABL myristoyl pocket (STAMP mechanism), which differs from traditional TKIs that bind to the ATP site. This allows it to inhibit BCR-ABL1 activity even in cases where other tyrosine kinase inhibitors are no longer effective.
Scemblix is taken orally, typically twice daily. Common side effects may include musculoskeletal pain, fatigue, and low blood cell counts. Patients should be monitored for heart function and blood pressure changes. It may interact with other medications and should be taken as prescribed by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy