Sebetralstat
Sebetralstat is an oral on-demand treatment for hereditary angioedema (HAE) that works by inhibiting plasma kallikrein, the enzyme responsible for producing bradykinin. By blocking this pathway, it reduces the bradykinin-mediated swelling attacks characteristic of HAE.
Sebetralstat is an oral plasma kallikrein inhibitor used for on-demand treatment of hereditary angioedema attacks.
Key facts at a glance
- ATC
- B06AC08
- RxNorm
- 2717944
- Generic
- Sebetralstat
- Class
- atc-b06
- Brands
- Ekterly
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sebetralstat is indicated for the on-demand treatment of hereditary angioedema (HAE) attacks in adults and children. HAE is a rare genetic disorder caused by C1 inhibitor deficiency, leading to recurrent episodes of swelling in various parts of the body including the abdomen, face, hands, feet, and throat.
Sebetralstat is a competitive, reversible inhibitor of plasma kallikrein, a serine protease. It blocks the enzyme from cleaving high molecular weight kininogen (HK), which prevents the release of bradykinin. Since bradykinin is the key mediator that increases vascular permeability and causes swelling in HAE, inhibiting its production helps reduce attack severity and duration.
Sebetralstat is taken orally at the onset of an HAE attack, making it a convenient option for on-demand treatment. It is not intended for prophylaxis (routine prevention). Patients should have an updated HAE action plan and seek emergency care for throat swelling or severe abdominal attacks. As with all HAE treatments, individual response may vary, and this medication should be used under healthcare provider guidance.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy