Celecoxib
Seglentis is a prescription combination medication containing celecoxib (an anti-inflammatory) and tramadol (an opioid pain reliever). It is FDA-approved for the management of acute pain severe enough to require an opioid analgesic when other treatments are insufficient. This medication is typically prescribed for short-term use in adults.
Seglentis combines an NSAID with an opioid to treat moderate to severe acute pain.
Key facts at a glance
- RxNorm
- 2588479
- Generic
- Seglentis
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Seglentis is indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It is approved for use in adults and is typically prescribed for short-term treatment (typically 14 days or less).
Seglentis combines two active ingredients with complementary mechanisms: celecoxib, a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting the cyclooxygenase-2 enzyme; and tramadol, an atypical opioid analgesic that binds to mu-opioid receptors and inhibits reuptake of norepinephrine and serotonin to modulate pain signals.
Seglentis carries a boxed warning for addiction, abuse, and misuse risks, as well as serious respiratory depression and opioid use disorder risks. It should not be used in patients with known GI bleeding, severe renal impairment, or in the perioperative period of coronary artery bypass graft surgery. Common side effects include nausea, headache, dizziness, and somnolence. Seglentis is classified as a Schedule IV controlled substance due to the tramadol component. Use may increase risk of serotonin syndrome and seizures.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy