Seladelpar
Seladelpar is a peroxisome proliferator-activated receptor (PPAR)-delta agonist used for managing Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease affecting the bile ducts.
Seladelpar is a PPAR-delta agonist used to treat Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease, in patients who need additional therapy beyond first-line treatment.
Key facts at a glance
- ATC
- A05AX07
- RxNorm
- 2690869
- Generic
- Seladelpar
- Class
- atc-a05
- Brands
- Livdelzi
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of Primary Biliary Cholangitis (PBC), a chronic autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. Used in combination with ursodeoxycholic acid (UDCA) for patients with inadequate response to UDCA alone, or as monotherapy for those who cannot tolerate UDCA.
Seladelpar is a selective peroxisome proliferator-activated receptor (PPAR)-delta agonist. Activation of PPAR-delta influences lipid metabolism and inflammatory pathways. The precise therapeutic mechanism in PBC is not fully characterized, though the drug demonstrates pharmacological activity that is relevant to its therapeutic effects.
Requires regular monitoring of liver function tests. May cause pruritus (itching), headache, and gastrointestinal symptoms. Clinical trials showed significant improvements in biochemical markers of cholestasis. Patients should be advised to report any signs of liver problems. Safety during pregnancy should be discussed with healthcare providers.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy