Selexipag
Selexipag is an oral prostacyclin receptor (IP receptor) agonist used to treat pulmonary arterial hypertension (PAH). It works by activating IP receptors on vascular smooth muscle, causing pulmonary vasodilation and reducing pulmonary vascular resistance. The medication is converted by carboxylesterase 1 into an active metabolite that is approximately 37 times more potent than the parent compound.
An oral prostacyclin receptor agonist used to treat pulmonary arterial hypertension by dilating pulmonary blood vessels.
Key facts at a glance
- ATC
- B01AC27
- RxNorm
- 1729002
- Generic
- Selexipag
- Class
- atc-b01
- Brands
- Uptravi
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce the need for hospitalization. It may be used alone or in combination with other PAH therapies.
Selexipag is a prostacyclin receptor agonist that is hydrolyzed by carboxylesterase 1 to produce its active metabolite. The active metabolite activates IP receptors, causing relaxation of pulmonary vascular smooth muscle, which leads to vasodilation and reduced pulmonary vascular resistance.
Take as directed by your healthcare provider, typically twice daily. Common side effects may include headache, diarrhea, jaw pain, and nausea. Inform your doctor if you have liver problems, as dosage adjustments may be needed. Do not stop taking this medication without consulting your healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy