Selpercatinib
Selpercatinib is a targeted therapy known as a RET inhibitor used to treat adults and children with certain cancers driven by RET gene alterations. It is specifically approved for RET-mutant medullary thyroid cancer, RET fusion-positive thyroid cancer, and RET fusion-positive non-small cell lung cancer.
Selpercatinib is a kinase inhibitor that targets RET-driven cancers including certain thyroid and lung cancers.
Key facts at a glance
- ATC
- L01EX22
- RxNorm
- 2370147
- Generic
- Selpercatinib
- Class
- atc-l01
- Brands
- Retevmo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Selpercatinib is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer, adults and children aged 12 and older with advanced or metastatic RET-mutant medullary thyroid cancer, and adults and children aged 12 and older with RET fusion-positive thyroid cancer who require systemic therapy.
Selpercatinib is a selective RET kinase inhibitor that blocks abnormal RET signaling caused by RET gene mutations or fusions. It also has activity against VEGFR1, VEGFR3, and FGFR1-3 at higher concentrations.
Common side effects include increased liver enzymes, fatigue, dry mouth, and hypertension. Selpercatinib may cause serious adverse events including hepatotoxicity, interstitial lung disease, hypertension, cardiac dysfunction, and tumor lysis syndrome. Patients should be monitored for these effects and dose modifications may be needed.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy