Sevabertinib
Sevabertinib is an antineoplastic agent classified as a targeted therapy that inhibits specific receptor kinases involved in cancer growth. It works by blocking HER2 and EGFR signaling pathways, which are commonly overactive in certain cancers and drive tumor cell proliferation.
Sevabertinib is a HER2 and EGFR kinase inhibitor used to treat cancers driven by these signaling pathways.
Key facts at a glance
- ATC
- L01EH06
- RxNorm
- 2728187
- Generic
- Sevabertinib
- Class
- atc-l01
- Brands
- Hyrnuo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Investigated for the treatment of HER2-positive malignancies, including certain breast and gastric cancers. Clinical trials are ongoing to determine its efficacy across various tumor types.
Sevabertinib is a reversible inhibitor that binds to the ATP-binding site of HER2 kinase, blocking phosphorylation and downstream signaling cascades including pathways involved in cell proliferation and survival. It also exhibits activity against EGFR.
As a targeted therapy, sevabertinib may cause side effects related to EGFR inhibition such as skin reactions. Patients should be monitored for potential cardiac effects and infusion reactions. Use under healthcare provider supervision with regular imaging and laboratory assessments.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy