Sevelamer
Sevelamer is a phosphate-binding medication used to control high phosphorus levels in the blood for patients with chronic kidney disease (CKD), particularly those on dialysis. It works by binding to dietary phosphate in the intestines, preventing its absorption into the bloodstream. This helps maintain healthy phosphate balance and reduces the risk of bone and cardiovascular complications associated with elevated phosphorus levels.
Sevelamer is a phosphate binder used to treat high blood phosphorus levels in patients with chronic kidney disease on dialysis.
Key facts at a glance
- ATC
- V03AE02
- RxNorm
- 214824
- Generic
- Sevelamer
- Class
- atc-v03
- Brands
- RenaGel, Renvela
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sevelamer is indicated for the control of serum phosphorus levels in patients with end-stage renal disease (ESRD) on dialysis, including hemodialysis and peritoneal dialysis. It is used to treat hyperphosphatemia in adult patients and pediatric patients aged 6 years and older with CKD.
Sevelamer is a non-absorbed, calcium-free phosphate-binding polymer. Its protonated amine groups bind to dietary phosphate in the intestine, forming an insoluble complex that is excreted in feces. By trapping phosphate in the GI tract, it prevents intestinal absorption and helps lower serum phosphate levels.
Sevelamer should be taken with meals as directed. Patients should be monitored for gastrointestinal side effects such as constipation, nausea, and diarrhea. The medication may reduce absorption of certain vitamins (D, E, K) and other drugs, so timing of other medications should be spaced apart. Regular monitoring of serum phosphate and bicarbonate levels is recommended.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy