Sibutramine
Sibutramine is an appetite suppressant medication previously used for weight loss in clinically obese patients, prescribed with a reduced-calorie diet and exercise program.
Sibutramine is a discontinued appetite suppressant once used for obesity that was withdrawn due to cardiovascular risks.
Key facts at a glance
- ATC
- A08AA10
- RxNorm
- 36514
- Generic
- Sibutramine
- Class
- atc-a08
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sibutramine was indicated for weight loss in patients with obesity (BMI ≥30 kg/m²) or overweight patients (BMI ≥27 kg/m²) with weight-related comorbidities such as hypertension, type 2 diabetes, or dyslipidemia.
Sibutramine acts as a serotonin-norepinephrine reuptake inhibitor (SNRI), increasing levels of these neurotransmitters in the brain to promote satiety, reduce appetite, and enhance feelings of fullness after eating.
Sibutramine was withdrawn from the US market in 2010 due to increased risk of serious cardiovascular events including heart attack and stroke. It was contraindicated in patients with cardiovascular disease, uncontrolled hypertension, history of stroke, and eating disorders. Treatment required regular monitoring of blood pressure and heart rate.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy