Pasireotide
Signifor (pasireotide) is a prescription somatostatin analog used to treat Cushing's disease when surgery hasn't been successful or isn't an option, and for certain patients with acromegaly. It works by mimicking somatostatin to reduce excess hormone production, helping to control symptoms associated with these conditions.
A somatostatin analog injection used for Cushing's disease and acromegaly to reduce excess hormone levels.
Key facts at a glance
- RxNorm
- 1364110
- Generic
- Signifor
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Cushing's disease (when surgery is not an option or has not been successful) and acromegaly in adults who have not responded adequately to other treatments.
As a somatostatin analog, it binds to somatostatin receptors and inhibits the secretion of adrenocorticotropic hormone (ACTH), which reduces cortisol production in Cushing's disease, and reduces growth hormone and IGF-1 levels in acromegaly.
Administered by subcutaneous injection, typically twice daily. Common side effects include hyperglycemia, diarrhea, nausea, abdominal pain, gallstones, and injection site reactions. Requires blood glucose monitoring, especially in diabetic patients. Should be used with caution in patients with diabetes, liver impairment, or cardiac conditions.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy