Dexmedetomidine
Sileo is a prescription medication for dogs designed to treat noise aversion, helping calm pets affected by loud sounds such as fireworks and thunderstorms. It is administered as an oromucosal gel and is the first FDA-approved treatment specifically indicated for canine noise aversion. This medication helps reduce anxiety and fear responses in dogs during stressful noise events.
Sileo is an FDA-approved oromucosal gel for dogs that treats noise aversion and anxiety related to loud sounds like fireworks and thunderstorms.
Key facts at a glance
- RxNorm
- 1732669
- Generic
- Sileo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sileo is indicated for the treatment of noise aversion in dogs, helping to manage fear and anxiety triggered by loud noises such as fireworks, thunderstorms, construction sounds, and other environmental noises that cause distress.
Sileo contains dexmedetomidine, an alpha-2 adrenergic agonist that produces sedation and anxiolytic effects by decreasing sympathetic nervous system activity. The oromucosal gel formulation allows for transmucosal absorption, providing a calming effect within 30-60 minutes of administration.
Sileo should only be used in dogs as prescribed by a veterinarian. It is contraindicated in dogs with certain cardiovascular conditions, severe debilitation, or sedation sensitivity. Dosage is weight-based and should not exceed the maximum recommended dose. Side effects may include sedation, pale gums, and gastrointestinal symptoms. Pet owners should consult their veterinarian before use, especially if the dog has any underlying health conditions or is taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy