Brodalumab
Siliq (brodalumab) is a prescription biologic medication used to treat moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. It is administered by subcutaneous injection and works by targeting the interleukin-17 (IL-17) pathway, which plays a key role in the inflammatory process underlying psoriasis.
Siliq is an injectable biologic medication for adults with moderate to severe plaque psoriasis that works by blocking the IL-17 inflammatory pathway.
Key facts at a glance
- RxNorm
- 1872257
- Generic
- Siliq
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Siliq is indicated for the treatment of moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond to or lost response to other systemic treatments.
Siliq is a monoclonal antibody that binds to the interleukin-17 receptor A (IL-17RA), blocking the activity of several IL-17 cytokines involved in inflammation. By inhibiting this pathway, it reduces the inflammatory response that contributes to psoriasis symptoms.
Siliq is administered by subcutaneous injection and requires a healthcare provider to confirm patient eligibility through a special program due to safety considerations, including a boxed warning regarding suicidal behavior. Common side effects may include joint pain, headache, fatigue, and injection site reactions. Patients should be monitored for signs of infection or depression during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy