Brinzolamide and Brimonidine
Simbrinza is a prescription eye drop combination medication used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It contains two active ingredients that work together to reduce fluid production in the eye, helping to prevent vision loss from elevated eye pressure.
Simbrinza is an ophthalmic combination medication used to reduce eye pressure in glaucoma patients.
Key facts at a glance
- RxNorm
- 1421452
- Generic
- Simbrinza
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Simbrinza is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who require adjunctive or alternative therapy.
Simbrinza combines brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist) to reduce aqueous humor production in the eye, thereby lowering intraocular pressure through complementary mechanisms.
Simbrinza is for topical ophthalmic use only. Patients should remove contact lenses before administration and wait at least 15 minutes before reinserting. Common side effects may include eye redness, eye discomfort, and taste changes. Patients with certain respiratory or cardiovascular conditions should use caution and discuss their medical history with their doctor before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy