Sarolaner
Simparica Trio is a monthly chewable medication for dogs that provides comprehensive protection against fleas, ticks, heartworm disease, and certain intestinal parasites. It combines three active ingredients to address multiple parasites in a single dose, making parasite prevention more convenient for pet owners. This medication is specifically formulated for dogs and requires a veterinary prescription.
Simparica Trio is a monthly chewable parasiticide for dogs that protects against fleas, ticks, heartworms, and intestinal worms.
Key facts at a glance
- RxNorm
- 2281737
- Generic
- Simparica Trio
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Simparica Trio is used to prevent flea infestations, treat and control tick infestations (including multiple tick species), prevent heartworm disease caused by Dirofilaria immitis, and treat and control roundworm and hookworm infections in dogs.
Simparica Trio contains three active ingredients: sarolaner kills fleas and ticks through GABA-gated chloride channel antagonism; moxidectin prevents heartworm disease by disrupting the parasite's nervous system; and pyrantel pamoate paralyzes and expels intestinal worms by causing neuromuscular blockade.
Simparica Trio is for use in dogs only and must be tested for existing heartworm infection before starting treatment. It should be given monthly year-round for optimal protection. Potential side effects may include vomiting, diarrhea, lethargy, and in rare cases, neurological signs. Always consult with a veterinarian before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy