Basiliximab
Simulect (basiliximab) is an immunosuppressant medication used to prevent acute organ rejection in patients receiving kidney transplants. It is a monoclonal antibody that works by blocking a specific receptor on immune cells, reducing their ability to attack the transplanted organ. This medication is typically used as part of a broader immunosuppressive regimen that may include other drugs.
Simulect is an immunosuppressant monoclonal antibody used to prevent kidney transplant rejection.
Key facts at a glance
- RxNorm
- 219912
- Generic
- Simulect
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Simulect is indicated for the prophylaxis of acute organ rejection in patients receiving kidney transplants. It is specifically used as part of an immunosuppressive regimen that includes other anti-rejection medications, typically cyclosporine and corticosteroids.
Simulect is a chimeric monoclonal antibody that binds to the CD25 subunit (alpha chain) of the interleukin-2 (IL-2) receptor on the surface of activated T lymphocytes. By blocking this receptor, it prevents IL-2 from triggering T-cell activation and proliferation, thereby reducing the immune response against the transplanted organ.
Simulect is administered via intravenous infusion, typically in two doses around the time of transplantation. It should be used with caution in patients with a history of hypersensitivity reactions. As with all immunosuppressants, patients may be at increased risk for infections and certain malignancies. Women of childbearing potential should use effective contraception during and for 4 months after treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy