Siponimod
Siponimod is an S1P receptor modulator that reduces the number of lymphocytes circulating in the bloodstream by preventing their egress from lymph nodes. It is primarily used to treat certain forms of multiple sclerosis in adult patients.
An immunosuppressant that traps immune cells in lymph nodes to reduce inflammation in multiple sclerosis.
Key facts at a glance
- ATC
- L04AE03
- RxNorm
- 2121085
- Generic
- Siponimod
- Class
- atc-l04
- Brands
- Mayzent
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adult patients with secondary progressive multiple sclerosis (SPMS) with active disease, and relapsing forms of multiple sclerosis (RMS).
Siponimod binds to S1P receptors 1 and 5, blocking lymphocyte egress from lymph nodes and reducing peripheral blood lymphocyte counts, thereby decreasing immune-mediated inflammation in the central nervous system.
Requires cardiac monitoring before initiation due to potential bradycardia. May cause macular edema, liver injury, and respiratory effects. Contraindicated in patients with certain cardiac conditions. Regular blood tests are needed to monitor liver function and blood counts.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy