Sirolimus
Sirolimus is an immunosuppressant medication that prevents organ rejection by inhibiting T-lymphocyte activation and proliferation in response to antigenic and cytokine stimulation. It is primarily used to prevent rejection in kidney transplant patients and is also used to treat lymphangioleiomyomatosis (LAM), a rare lung disease.
An immunosuppressant that prevents organ rejection by blocking T-cell activation and antibody production.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01EG04
- RxNorm
- 35302
- Generic
- Sirolimus
- Class
- atc-l01
- Brands
- Rapamune, Fyarro, Hyftor, Felycin
- Availability
- rx
- Lactation
- unknown
- Routes
- oral, topical
- Forms
- tablet, gel, solution, injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of organ rejection in kidney transplant recipients; treatment of lymphangioleiomyomatosis (LAM), a rare progressive lung disease
Inhibits T-lymphocyte activation and proliferation in response to antigenic and cytokine stimulation (IL-2, IL-4, IL-15), working through a distinct mechanism from other immunosuppressants; also inhibits antibody production
Requires regular therapeutic drug monitoring due to narrow therapeutic window; significant drug interactions with CYP3A4 inhibitors and inducers; common adverse effects include hyperlipidemia, mouth ulcers, and edema; increases risk of infections and malignancy due to immunosuppression
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy