Afamelanotide
Skyclarys is a prescription medication used to treat Friedreich's ataxia in adults and adolescents aged 16 years and older. It works by activating the Nrf2 pathway, which helps reduce oxidative stress and mitochondrial dysfunction in cells. This oral medication is specifically indicated for patients with this rare genetic neurodegenerative disorder that causes progressive loss of coordination and muscle weakness.
Skyclarys is an Nrf2 activator used to slow disease progression in adults and adolescents with Friedreich's ataxia.
Key facts at a glance
- RxNorm
- 2631937
- Generic
- Skyclarys
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Skyclarys is indicated for the treatment of Friedreich's ataxia, a rare inherited neurodegenerative disorder that causes progressive loss of coordination, muscle weakness, and can affect the heart. It is approved for use in adults and adolescents 16 years of age and older.
Skyclarys activates the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway, which is a key regulator of cellular antioxidant and mitochondrial responses. By activating this pathway, the medication helps reduce oxidative stress and improve mitochondrial function in affected nerve and heart cells.
Skyclarys may cause liver problems and requires regular monitoring of liver function tests. Common side effects may include headache, nausea, fatigue, and musculoskeletal pain. Patients should inform their healthcare provider of all medications they are taking, as drug interactions may occur. This medication should not be used during pregnancy unless clearly necessary.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy