Sodium Acetate
Sodium acetate is an electrolyte solution used primarily as a source of sodium and acetate ions for treating sodium deficiencies and metabolic acidosis. It is commonly administered intravenously in clinical settings for fluid replacement, acid-base balance, and as a component of parenteral nutrition solutions.
Sodium acetate is an IV electrolyte supplement used to treat sodium depletion and metabolic acidosis during fluid replacement therapy.
Key facts at a glance
- ATC
- B05XA08
- RxNorm
- 56443
- Generic
- Sodium Acetate
- Class
- atc-b05
- Brands
- Clinimix E 4.25/10, Isolyte S in 5 % Dextrose, Normosol-R in 5 % Dextrose, Trophamine 10 %, Trophamine 6 %, Nutrilyte, Nutrilyte II, Isolyte S, Physiolyte, Physiosol, Normosol-R, Plasma-lyte 148, Plasmalyte A, Clinimix E 4.25/5, Clinimix E 2.75/5
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- ophthalmic
- Forms
- injection, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimesteruse only if clearly needed
use during pregnancy only when benefits outweigh potential risks
regular monitoring of fluid and electrolyte balance
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse only if clearly needed
use only when benefits outweigh risks, avoid high doses
close monitoring of maternal and fetal status
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
considered compatible with breastfeeding
monitor infant for electrolyte imbalances if high doses
pediatric_age
neonatesweight-based dosing required
use under close medical supervision, monitor serum electrolytes
frequent serum sodium, potassium, and bicarbonate monitoring
Use with caution and monitor for adverse effects.
pediatric_age
childrenweight-based dosing required
calculate dose based on body weight and clinical condition
regular serum electrolyte monitoring
Use with caution and monitor for adverse effects.
geriatric
elderlystart with lower dose, adjust based on renal function
use with caution due to decreased renal function common in elderly
monitor renal function, serum electrolytes, and fluid status
Use with caution and monitor for adverse effects.
renal_impairment
mildmonitor serum sodium levels
use with caution, monitor renal function tests
frequent serum sodium and creatinine monitoring
Use with caution and monitor for adverse effects.
renal_impairment
moderate to severeavoid or significantly reduce dose
avoid use in severe renal impairment unless benefits outweigh risks
frequent serum electrolytes and renal function monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
hepatic_impairment
mild to moderateno specific adjustment needed
generally safe, monitor liver function
monitor liver function tests and electrolytes
alcohol_users
chronic alcohol useuse with caution
monitor electrolytes closely as alcohol can affect electrolyte balance
frequent serum electrolyte monitoring
Use with caution and monitor for adverse effects.
Statistics and clinical data
Common uses
Used in parenteral nutrition and IV hydration solutions
Drug class
Classified as an electrolyte replacement agent
Commonly used since
IV solutions containing sodium acetate have been available for decades
Primary indication
Used as a source of bicarbonate precursor
Treatment of hyponatremia (low blood sodium), correction of metabolic acidosis, and maintenance of fluid balance. Also used as a component in IV infusion solutions and dialysate fluids for renal replacement therapy.
Sodium acetate dissociates into sodium and acetate ions when administered intravenously. The acetate component is metabolized in the body to produce bicarbonate, which helps neutralize acid and raise blood pH, while sodium helps restore electrolyte balance.
Administered exclusively by intravenous infusion under medical supervision. Electrolyte levels and acid-base status should be monitored during treatment. Use with caution in patients with heart failure, kidney impairment, or conditions involving sodium retention. Contraindicated in patients with metabolic or respiratory alkalosis.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy