Sodium Polystyrene Sulfonate
Sodium Polystyrene Sulfonate is a potassium-binding resin used to treat dangerously high potassium levels in the blood (hyperkalemia). It works by exchanging sodium ions for potassium ions in the intestines, allowing excess potassium to be removed from the body through stool. This medication is typically used in patients with kidney disease or those at risk of cardiac complications from elevated potassium.
A potassium-lowering resin that removes excess potassium from the body through the gastrointestinal tract.
Key facts at a glance
- RxNorm
- 56512
- Generic
- Sodium Polystyrene Sulfonate
- Class
- unclassified
- Brands
- SPS, Kionex
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hyperkalemia (elevated blood potassium levels), commonly used in patients with chronic kidney disease, those on dialysis, or individuals at risk of cardiac arrhythmias from high potassium.
This cation exchange resin binds to potassium in the gastrointestinal tract, exchanging sodium ions for potassium ions. The bound potassium is then eliminated through the feces rather than absorbed into the bloodstream.
May cause low potassium, low magnesium, or low calcium levels and should be used cautiously in patients with heart failure or hypertension due to its sodium content. Can cause constipation and should be taken with fluids. Oral administration is preferred; enema form used when oral intake is not possible. May interact with other medications by affecting their absorption.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy