Sofosbuvir
Sofosbuvir is a direct-acting antiviral (DAA) agent used to treat chronic hepatitis C virus (HCV) infection. It is a nucleotide analogue that inhibits the NS5B RNA polymerase, which is essential for viral replication. Sofosbuvir is typically used in combination with other antiviral medications and is effective across multiple hepatitis C genotypes.
A direct-acting antiviral medication used to treat chronic hepatitis C infection by inhibiting viral replication.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- J05AP08
- RxNorm
- 1484911
- Generic
- Sofosbuvir
- Class
- atc-j05
- Brands
- Sovaldi, Harvoni, Epclusa, Vosevi
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic hepatitis C virus (HCV) infection in adults. Used in combination with other antiviral agents (such as velpatasvir and ledipasvir) for multiple HCV genotypes. Often prescribed for patients who have not responded to previous hepatitis C treatments.
Sofosbuvir is a nucleotide analogue prodrug that is metabolized intracellularly to its active form (GS-461203). It acts as a faulty substrate for the HCV NS5B RNA-dependent RNA polymerase, causing chain termination and inhibiting viral RNA replication. This direct action on the virus prevents it from multiplying and spreading.
Must be used in combination with other antiviral medications as monotherapy is not recommended. Contraindicated in pregnancy and should not be used with certain drugs that may reduce efficacy. Ribavirin combination is contraindicated in pregnant women and male partners of pregnant women. Common side effects may include fatigue and headache. Regular monitoring of liver function is recommended during treatment. Should only be prescribed by qualified healthcare providers experienced in treating hepatitis C.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy