Paregoric
Sohonos (palovarotene) is a retinoic acid receptor agonist used to reduce heterotopic ossification (abnormal bone formation in soft tissues) in patients with fibrodysplasia ossificans progressiva (FOP). It is approved for females aged 8 years and older and males aged 10 years and older, making it the first approved treatment specifically for FOP.
Sohonos is a prescription medication for reducing abnormal bone formation in patients with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder.
Key facts at a glance
- RxNorm
- 2663961
- Generic
- Sohonos
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sohonos is indicated for reducing heterotopic ossification in patients with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder where soft tissues progressively transform into bone, leading to restricted movement and disability.
As a retinoic acid receptor agonist, Sohonos inhibits the ALK2/FOP signaling pathway, which is overactive in FOP patients due to genetic mutations, thereby reducing the formation of heterotopic ossification.
Sohonos is contraindicated in pregnancy due to severe teratogenic effects. Females of childbearing potential must use effective contraception during treatment. Common side effects include skin reactions, hypervitaminosis A symptoms, and premature epiphyseal closure may occur in pediatric patients. Treatment should be supervised by physicians experienced in managing FOP.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy