Somatrogon
Somatrogon is a long-acting recombinant human growth hormone (rhGH) used to treat growth hormone deficiency in pediatric patients. It works by binding to growth hormone receptors and activating the STAT5b signaling pathway, which increases Insulin-like Growth Factor (IGF-1) levels to promote growth and metabolic changes.
A long-acting growth hormone therapy for children with growth hormone deficiency that increases IGF-1 levels through GH receptor activation.
Key facts at a glance
- ATC
- H01AC08
- RxNorm
- 2644503
- Generic
- Somatrogon
- Class
- atc-h01
- Brands
- Ngenla
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of pediatric patients with growth hormone deficiency who have inadequate growth response to endogenous growth hormone production.
Somatrogon-ghla binds to the Growth Hormone (GH) receptor and initiates a signal transduction cascade, activating the STAT5b signaling pathway and increasing serum concentrations of Insulin-like Growth Factor (IGF-1), which promotes growth and metabolic changes.
Somatrogon is administered as a subcutaneous injection with less frequent dosing compared to daily growth hormone preparations. Patients should be monitored for potential side effects including headache, injection site reactions, and metabolic changes. Treatment should be supervised by an endocrinologist or pediatric growth specialist.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy