Sotatercept
Sotatercept is a recombinant activin receptor type IIA-Fc fusion protein used to treat pulmonary arterial hypertension (PAH). It works by binding to activin A and other TGF-β superfamily ligands, inhibiting activin signaling to improve the balance between pro-proliferative and anti-proliferative pathways in pulmonary vasculature, thereby reducing pulmonary vascular resistance.
Sotatercept is an injectable activin signaling inhibitor used for pulmonary arterial hypertension that works by binding TGF-β superfamily ligands to improve vascular balance.
Key facts at a glance
- ATC
- C02KX06
- RxNorm
- 2678930
- Generic
- Sotatercept
- Class
- atc-c02
- Brands
- Winrevair
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pulmonary arterial hypertension (PAH) in adults with WHO Group 1 PH as add-on therapy to background PAH treatments to improve exercise capacity.
Sotatercept is a fusion protein consisting of the extracellular domain of activin receptor type IIA fused to an Fc fragment. It acts as a ligand trap, binding activin A and other TGF-β superfamily ligands to inhibit activin signaling. This restores the balance between pro-proliferative (ActRIIA) and anti-proliferative pathways, reducing pulmonary vascular remodeling and resistance.
Administered as a subcutaneous injection, typically every 3 weeks. May cause thrombocytopenia and requires regular blood monitoring. Contraindicated in pregnancy due to potential fetal harm. Women of reproductive potential should use effective contraception during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy