Isotretinoin
Sotret is a brand-name formulation of isotretinoin, a powerful oral retinoid used to treat severe, treatment-resistant nodular acne that has not responded to conventional therapies. It works by reducing sebum production, normalizing skin cell turnover, and decreasing inflammation in the skin.
Sotret is a potent acne medication for severe nodular acne that requires careful monitoring due to significant side effects.
Key facts at a glance
- RxNorm
- 405330
- Generic
- Sotret
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of severe, recalcitrant nodular acne that has not responded to conventional therapies including antibiotics. Typically reserved for cases with significant scarring risk or psychological impact.
Isotretinoin works through multiple mechanisms: it significantly reduces sebum production by shrinking sebaceous glands, normalizes follicular keratinization to prevent pore clogging, has anti-inflammatory properties, and may reduce Cutibacterium acnes bacteria on the skin.
Highly teratogenic—strict pregnancy prevention required (iPLEDGE program). Common side effects include severe dry skin, chapped lips, and photosensitivity. Requires regular monitoring of liver function and lipid levels. May cause mood changes; patients should be monitored for depression. Treatment is typically limited to one course of 15-20 weeks.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy