Deucravacitinib
Sotyktu is a prescription oral medication used to treat moderate to severe plaque psoriasis in adults who require systemic therapy. It works by selectively inhibiting TYK2, an enzyme involved in inflammatory signaling pathways that contribute to psoriasis. This medication is taken once daily and is intended for patients who are candidates for systemic treatment.
Sotyktu is an oral TYK2 inhibitor used to treat moderate to severe plaque psoriasis in adults.
Key facts at a glance
- RxNorm
- 2612093
- Generic
- Sotyktu
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sotyktu is FDA-approved for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Sotyktu is a selective tyrosine kinase 2 (TYK2) inhibitor. By blocking TYK2, it suppresses inflammatory signaling pathways (including IL-12, IL-23, and type I interferon) that drive the overactive immune response and skin cell turnover characteristic of psoriasis.
Sotyktu is taken as a once-daily oral tablet. It carries boxed warnings for serious infections, malignancy, and major adverse cardiovascular events (MACE). Patients should be screened for tuberculosis before starting treatment. It is contraindicated in patients with known hypersensitivity to deucravacitinib or any of its components.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy