Sparfloxacin
Sparfloxacin is a fluoroquinolone antibiotic that was used to treat various bacterial infections, particularly respiratory tract infections such as pneumonia and bronchitis. It works by inhibiting bacterial enzymes essential for DNA replication, effectively killing or stopping the growth of susceptible bacteria.
Sparfloxacin is a fluoroquinolone antibiotic for bacterial infections, particularly respiratory infections, that has been discontinued in many markets due to safety concerns.
Key facts at a glance
- ATC
- J01MA09
- RxNorm
- 18469
- Generic
- Sparfloxacin
- Class
- atc-j01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Sparfloxacin was indicated for the treatment of community-acquired pneumonia, acute exacerbations of chronic bronchitis, and other respiratory tract infections caused by susceptible bacteria. It was also used for urinary tract infections and skin infections.
As a fluoroquinolone, sparfloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This action prevents bacterial cell division and leads to bacterial death.
Sparfloxacin has been withdrawn from the US market and many other countries due to safety concerns including QT prolongation (heart rhythm abnormalities) and photosensitivity reactions. Like all fluoroquinolones, it may cause tendinitis and tendon rupture. It should be avoided in patients with known QT prolongation, those taking antiarrhythmic drugs, and during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy