Sodium Polystyrene Sulfonate
Sodium Polystyrene Sulfonate (SPS) is a potassium-binding medication used to treat hyperkalemia, a condition of elevated potassium levels in the blood that can lead to dangerous heart rhythm abnormalities. It works by exchanging sodium ions for potassium ions in the intestines, allowing excess potassium to be eliminated from the body through the digestive tract.
SPS is a brand-name medication used to lower high blood potassium levels by removing potassium through the intestines.
Key facts at a glance
- RxNorm
- 1799649
- Generic
- Sps
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
SPS is primarily indicated for the treatment of hyperkalemia (elevated blood potassium levels), a potentially life-threatening condition that can cause cardiac arrhythmias and muscle weakness. It is typically used when dietary potassium restriction and other measures are insufficient to control potassium levels.
SPS is a cation exchange resin that binds to potassium in the gastrointestinal tract. As the medication passes through the intestines, it exchanges sodium ions for potassium ions, allowing excess potassium to be removed from the body through fecal elimination.
SPS may cause electrolyte imbalances, particularly low calcium or magnesium levels, and gastrointestinal side effects such as constipation. It should be used with caution in patients with heart failure, hypertension, or kidney disease due to its sodium content. Patients should follow dietary recommendations regarding potassium intake while on this medication and report any signs of electrolyte disturbance to their healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy