Stiripentol
Stiripentol (DIACOMIT) is an anticonvulsant medication used as adjunctive therapy for the treatment of seizures associated with Dravet syndrome, a rare and severe form of epilepsy that begins in infancy. It is typically prescribed alongside other antiepileptic medications such as clobazam.
Stiripentol is an anticonvulsant used to treat seizures in patients with Dravet syndrome.
Key facts at a glance
- ATC
- N03AX17
- RxNorm
- 2054968
- Generic
- Stiripentol
- Class
- atc-n03
- Brands
- Diacomit
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Stiripentol is indicated as adjunctive therapy for the treatment of seizures associated with Dravet syndrome in patients taking clobazam. It is not approved for use as monotherapy.
The exact mechanism is unknown; however, it is thought to work through direct effects on GABA-A receptors, enhancing inhibitory neurotransmission, and through indirect effects by inhibiting cytochrome P450 enzymes, which may increase levels of other anticonvulsant medications.
Common side effects include drowsiness, decreased appetite, weight loss, nausea, and behavioral changes. Due to CYP450 inhibition, it has significant drug interactions with many other medications. Regular monitoring of weight and blood counts may be required. Use during pregnancy should be carefully considered only if the benefit justifies the risk to the fetus.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy