Regorafenib
Stivarga (regorafenib) is a prescription oral multikinase inhibitor used to treat adults with metastatic colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (liver cancer). It works by targeting multiple proteins that cancer cells need to grow and spread, helping to slow disease progression. This medication is typically used after other treatments have failed.
Stivarga is an oral cancer medication used for colorectal, GIST, and liver cancers that works by inhibiting multiple cancer-promoting proteins.
Key facts at a glance
- RxNorm
- 1312403
- Generic
- Stivarga
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Stivarga is indicated for the treatment of metastatic colorectal cancer (mCRC) in patients who have previously received certain chemotherapy regimens; gastrointestinal stromal tumors (GIST) in patients with inoperable or metastatic disease who have progressed on imatinib and sunitinib; and hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib.
Stivarga is a multikinase inhibitor that blocks multiple enzymes (kinases) involved in tumor growth, angiogenesis (blood vessel formation to tumors), and cancer cell spread. By inhibiting these pathways, it helps slow the progression of certain cancers.
Stivarga may cause severe liver problems, including liver failure. Common side effects include fatigue, loss of appetite, hand-foot skin reaction (palmar-plantar erythrodysesthesia), diarrhea, hypertension, and voice changes. It may increase risk of bleeding, heart attack, and gastrointestinal perforation. Patients should avoid grapefruit juice and should not be used during pregnancy. Regular blood tests to monitor liver function are required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy