Streptococcus Pneumoniae Serotype 1 Conjugate Vaccine
This is a conjugate vaccine designed to protect against Streptococcus pneumoniae serotype 1, a bacteria responsible for serious infections like pneumonia, meningitis, and bloodstream infections. The vaccine works by linking the capsular polysaccharide antigen to a diphtheria CRM197 protein carrier, which helps stimulate a stronger and longer-lasting immune response, particularly in young children who typically have weaker responses to polysaccharide-only vaccines.
A pneumococcal conjugate vaccine targeting serotype 1 that protects against invasive pneumococcal disease through immune system stimulation.
Key facts at a glance
- RxNorm
- 901620
- Generic
- Streptococcus Pneumoniae Serotype 1 Capsular Antigen Diphtheria Crm197 Protein Conjugate Vaccine
- Class
- unclassified
- Brands
- Prevnar 20, Vaxneuvance, Prevnar 13
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of invasive pneumococcal disease, pneumonia, meningitis, and bacteremia caused by Streptococcus pneumoniae serotype 1. Used in populations at risk for pneumococcal infections, including young children, elderly individuals, and those with compromised immune systems or chronic health conditions.
The vaccine contains purified capsular polysaccharides from S. pneumoniae serotype 1, chemically conjugated to CRM197, a nontoxic mutant of diphtheria toxin. This conjugation converts the T-cell independent polysaccharide antigen into a T-cell dependent antigen, enabling stronger antibody responses, immunological memory, and effective protection in populations like infants who respond poorly to polysaccharide vaccines alone.
Like all vaccines, effectiveness varies by individual and may not prevent infection in all recipients. Contraindications include severe allergic reactions to any vaccine component. Common side effects may include injection site reactions, fever, and irritability. Schedule and recommendations vary by country and target population. This vaccine is typically administered as part of broader pneumococcal immunization programs.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 30, 2026. · Read our editorial policy