Streptococcus Pneumoniae Serotype 12F Conjugate Vaccine
This vaccine targets Streptococcus pneumoniae serotype 12F, a strain associated with invasive pneumococcal disease. It is a conjugate vaccine that links capsular polysaccharides to the CRM197 carrier protein, a non-toxic mutant of diphtheria toxin, to enhance immune response, particularly in populations with weaker responses to polysaccharide antigens alone such as young children or immunocompromised individuals.
A pneumococcal conjugate vaccine targeting serotype 12F using diphtheria CRM197 protein carrier to prevent invasive pneumococcal disease.
Key facts at a glance
- RxNorm
- 2566293
- Generic
- Streptococcus Pneumoniae Serotype 12f Capsular Antigen Diphtheria Crm197 Protein Conjugate Vaccine
- Class
- unclassified
- Brands
- Prevnar 20, Capvaxive
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This vaccine is designed to provide active immunization against Streptococcus pneumoniae serotype 12F, which can cause invasive pneumococcal disease including pneumonia, bacteremia, and meningitis. Serotype 12F is one of the serotypes included in broader pneumococcal vaccines like PPSV23 (Pneumovax 23).
The vaccine contains purified capsular antigen from S. pneumoniae serotype 12F conjugated to CRM197 protein carrier. This conjugation converts the T-independent polysaccharide antigen into a T-dependent antigen, producing stronger antibody responses and immunological memory, particularly important in young children and immunocompromised patients who respond poorly to unconjugated polysaccharide vaccines.
This is a serotype-specific conjugate vaccine. Clinical use and availability may vary by country. General pneumococcal conjugate vaccine precautions apply including screening for severe allergies to vaccine components. Consult current local guidelines for specific recommendations regarding pneumococcal immunization schedules.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 30, 2026. · Read our editorial policy