Streptococcus Pneumoniae Serotype 15A Conjugate Vaccine
This is a conjugate vaccine designed to provide active immunization against Streptococcus pneumoniae serotype 15a. The vaccine works by conjugating the capsular antigen of serotype 15a to the non-toxic CRM197 protein derived from diphtheria toxin, which helps enhance the immune response, particularly in young children whose immune systems may not respond adequately to polysaccharide antigens alone. It is used for the prevention of invasive pneumococcal disease, pneumonia, and otitis media caused by this specific serotype.
A pneumococcal conjugate vaccine targeting serotype 15a that prevents invasive pneumococcal disease through enhanced immune response via CRM197 protein conjugation.
Key facts at a glance
- RxNorm
- 2686917
- Generic
- Streptococcus Pneumoniae Serotype 15a Capsular Antigen Diphtheria Crm197 Protein Conjugate Vaccine
- Class
- unclassified
- Brands
- Capvaxive
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of invasive pneumococcal disease, pneumonia, bacteremia, meningitis, and acute otitis media caused by Streptococcus pneumoniae serotype 15a. This serotype is included to expand coverage beyond traditional conjugate vaccines, addressing a serotype with increasing prevalence in pneumococcal infections.
The vaccine contains the capsular polysaccharide antigen of S. pneumoniae serotype 15a, chemically conjugated to the CRM197 protein (a non-toxic mutant of diphtheria toxin). This conjugation converts a T-cell independent antigen into a T-cell dependent antigen, enhancing immunogenicity and inducing stronger antibody responses, particularly in infants and young children. The conjugate vaccine also enables immunological memory for long-term protection.
This is a prophylactic vaccine, not a treatment for active infection. As a serotype-specific vaccine, it does not provide protection against other pneumococcal serotypes or non-typeable strains. Side effects may include injection site reactions, fever, and irritability. Contraindications include severe hypersensitivity to any vaccine component. Efficacy and safety data specific to this serotype 15a formulation should be consulted for dosing schedules.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 30, 2026. · Read our editorial policy