Streptococcus Pneumoniae Serotype 3 Conjugate Vaccine
This is a monovalent pneumococcal conjugate vaccine that targets Streptococcus pneumoniae serotype 3. The serotype-specific capsular antigen is conjugated to CRM197 protein, a nontoxic mutant of diphtheria toxin, to enhance the immune response. This conjugation strategy converts the polysaccharide antigen into a T-cell dependent antigen, resulting in improved immunogenicity and immunological memory compared to unconjugated polysaccharides.
A conjugate vaccine designed to prevent pneumococcal disease caused by Streptococcus pneumoniae serotype 3 by using a protein-conjugated approach to enhance immune response.
Key facts at a glance
- RxNorm
- 901628
- Generic
- Streptococcus Pneumoniae Serotype 3 Capsular Antigen Diphtheria Crm197 Protein Conjugate Vaccine
- Class
- unclassified
- Brands
- Prevnar 20, Vaxneuvance, Capvaxive, Prevnar 13
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This vaccine is designed to provide active immunization against Streptococcus pneumoniae serotype 3, a capsular type associated with invasive pneumococcal disease including pneumonia, bacteremia, and meningitis. It may be used as part of a broader pneumococcal vaccination strategy.
The vaccine contains the capsular polysaccharide antigen from S. pneumoniae serotype 3, chemically linked to CRM197 protein carrier. This conjugation converts a T-cell independent polysaccharide antigen into a T-cell dependent antigen, enabling a stronger antibody response, immunologic memory, and effectiveness in young children who typically respond poorly to polysaccharide antigens alone.
As with all vaccines, contraindications include known hypersensitivity to any vaccine component. Conjugate vaccines may be administered alongside other routine childhood vaccines. Immunogenicity and safety profiles should be evaluated according to specific product labeling. Consult current official immunization guidelines for age recommendations and scheduling.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 30, 2026. · Read our editorial policy