Streptococcus Pneumoniae Serotype 35B Conjugate Vaccine
This is a monovalent conjugate vaccine designed to provide protection against Streptococcus pneumoniae serotype 35b, a bacterium that can cause respiratory infections, pneumonia, and invasive disease. The vaccine works by linking the capsular polysaccharide antigen of serotype 35b to the CRM197 protein, a nontoxic mutant of diphtheria toxin that serves as a carrier to enhance immune response. Such conjugate vaccines are particularly valuable for inducing stronger and more durable immune responses in young children, where plain polysaccharide vaccines are less effective.
A targeted pneumococcal vaccine using CRM197 conjugate technology to prevent serotype 35b infections, primarily for populations at risk for this specific strain.
Key facts at a glance
- RxNorm
- 2686925
- Generic
- Streptococcus Pneumoniae Serotype 35b Capsular Antigen Diphtheria Crm197 Protein Conjugate Vaccine
- Class
- unclassified
- Brands
- Capvaxive
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of invasive pneumococcal disease, pneumonia, and other infections caused by Streptococcus pneumoniae serotype 35b. May be considered for specific populations with increased risk from this serotype or in outbreak settings where serotype 35b is prevalent.
The vaccine contains the capsular polysaccharide from S. pneumoniae serotype 35b, chemically conjugated to the CRM197 carrier protein. This conjugation converts the immune response from T-cell independent (typical of polysaccharides alone) to T-cell dependent, resulting in stronger antibody responses, immunological memory, and effectiveness in young children.
Like other conjugate vaccines, this product may cause local injection site reactions and systemic effects like fever. Contraindications include severe hypersensitivity to any vaccine component. Efficacy and safety data specific to serotype 35b should be consulted. Not a substitute for standard pneumococcal vaccines covering multiple serotypes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy