Streptozocin
Streptozocin is a chemotherapy medication classified as a nitrosourea alkylating agent, primarily used to treat certain pancreatic neuroendocrine tumors, including insulinomas and other islet cell carcinomas. It works by interfering with DNA synthesis in cancer cells, leading to cell death, and is often administered in combination with other chemotherapy agents such as fluorouracil.
Streptozocin is a chemotherapy drug used to treat pancreatic neuroendocrine tumors by damaging cancer cell DNA.
Key facts at a glance
- ATC
- L01AD04
- RxNorm
- 10114
- Generic
- Streptozocin
- Class
- atc-l01
- Brands
- Zanosar
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for metastatic pancreatic neuroendocrine tumors and islet cell carcinomas, including insulinomas and gastrinomas. May be used when surgical removal is not possible or for recurrent disease.
As a nitrosourea alkylating agent, streptozocin transfers alkyl groups to DNA molecules, causing cross-linking and strand breaks that prevent cancer cells from replicating and dividing properly, ultimately leading to cell death.
Administered intravenously under medical supervision. Common side effects include nausea, vomiting, diarrhea, and kidney toxicity. Requires regular monitoring of kidney function and blood glucose levels. May cause severe hypoglycemia in insulinoma patients and should be used with caution in patients with compromised renal function.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy