Sucroferric Oxyhydroxide
Sucroferric oxyhydroxide is an iron-based phosphate binder used to treat elevated serum phosphorus levels (hyperphosphatemia) in patients with chronic kidney disease, particularly those on dialysis. It works by binding dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream and allowing it to be eliminated in feces.
A phosphate-binding medication that helps chronic kidney disease patients manage high phosphorus levels by trapping dietary phosphate in the gut for fecal elimination.
Key facts at a glance
- ATC
- V03AE05
- RxNorm
- 1484283
- Generic
- Sucroferric Oxyhydroxide
- Class
- atc-v03
- Brands
- Velphoro
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hyperphosphatemia in adult patients with chronic kidney disease (CKD), including those receiving dialysis. It helps control serum phosphorus levels when dietary phosphate restriction alone is insufficient.
Sucroferric oxyhydroxide contains iron in the form of a polynuclear iron(III)-oxyhydroxide complex. In the gastrointestinal tract, phosphate ions from the diet undergo ligand exchange with hydroxyl groups and water molecules on the iron oxyhydroxide surface, forming an insoluble iron-phosphate complex that is excreted in feces.
This is a non-calcium-based phosphate binder, which may be advantageous for patients needing to avoid calcium supplementation. It is taken orally with meals. Common side effects may include discolored stools (which is expected and harmless), diarrhea, and GI disturbances. Iron levels should be monitored periodically.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy