Sulfanilamide
Sulfanilamide is an antibacterial medication belonging to the sulfonamide class of antibiotics. It works by inhibiting bacterial folate synthesis, which is essential for bacterial growth and replication. This medication has been used in topical formulations for various skin infections and conditions.
Sulfanilamide is an older sulfonamide antibiotic used topically to treat bacterial skin infections by inhibiting folate synthesis in susceptible organisms.
Key facts at a glance
- ATC
- D06BA05
- RxNorm
- 10184
- Generic
- Sulfanilamide
- Class
- atc-d06
- Brands
- Negasunt
- Availability
- rx
- Lactation
- unknown
- Routes
- topical, vaginal
- Forms
- powder
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Topical treatment of skin infections, including bacterial vaginosis when formulated as vaginal creams or suppositories, and various dermatological conditions caused by susceptible organisms.
Sulfanilamide acts as a competitive inhibitor of dihydropteroate synthase, blocking the bacterial folate synthesis pathway essential for nucleic acid production and bacterial replication.
May cause allergic reactions, particularly in patients with sulfonamide sensitivity. Avoid use in late pregnancy near term. Topical use generally preferred over systemic administration. Effectiveness may be limited against some modern bacterial strains.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy