Sulfathiazole
Sulfathiazole is a sulfonamide antibiotic that works by inhibiting bacterial folate synthesis, preventing the growth of susceptible bacteria. Historically used to treat various bacterial infections including urinary tract infections and certain skin infections, though it has largely been replaced by newer, safer antibiotics in modern clinical practice.
Sulfathiazole is an older sulfonamide antibiotic previously used for bacterial infections, now rarely prescribed due to the availability of safer alternatives.
Key facts at a glance
- ATC
- D06BA02
- RxNorm
- 10193
- Generic
- Sulfathiazole
- Class
- atc-d06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- vaginal
- Forms
- cream
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Topically for minor skin infections, burns, and wound care. Historically also used systemically for urinary tract infections and other susceptible bacterial infections, though oral use is now uncommon.
Sulfathiazole is a competitive inhibitor of bacterial dihydropteroate synthase, blocking the synthesis of dihydrofolic acid and subsequently impairing bacterial DNA synthesis and replication.
May cause hypersensitivity reactions, including skin rashes and blood disorders. Use with caution in patients with sulfa allergies, renal impairment, or porphyria. Generally contraindicated in late pregnancy due to risk of kernicterus in newborns. Effectiveness may be reduced in patients with impaired renal function.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy