Sulfamethoxazole and Trimethoprim
Sulfatrim is a brand-name combination antibiotic containing sulfamethoxazole and trimethoprim. This medication is used to treat various bacterial infections including urinary tract infections, respiratory infections, ear infections, and traveler's diarrhea. It works by targeting two different steps in the bacterial folic acid synthesis pathway, providing synergistic antibacterial activity.
Sulfatrim is a brand-name combination antibiotic used to treat bacterial infections by blocking folate synthesis in susceptible organisms.
Key facts at a glance
- RxNorm
- 220091
- Generic
- Sulfatrim
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of urinary tract infections, bronchitis, ear infections, gastrointestinal infections (such as traveler's diarrhea), and Pneumocystis jirovecii pneumonia. May also be used for other bacterial infections as determined by a healthcare provider.
Contains two active ingredients that work synergistically: sulfamethoxazole inhibits dihydropteroate synthase and trimethoprim inhibits dihydrofolate reductase, blocking consecutive steps in bacterial folic acid synthesis.
Contraindicated in patients with sulfa drug allergy, severe kidney impairment, or during late pregnancy. May cause photosensitivity, hyperkalemia, or kidney dysfunction. Regular monitoring of blood counts and kidney function may be needed during prolonged therapy. Avoid alcohol during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy